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Deagglomeration of DNA nanomedicine carriers using controlled ultrasonication

Ultrasound sonication is a well-established mechanism for the deagglomeration of particle materials in dispersion. In this recently published paper, the National Physical Laboratory investigates the deagglomeration of Nuvec® silica particles with and without the presence of plasmid via controlled sonication. It evaluated the performance of controlled cavitation using different powers and at different stages of preparation, for example, before and after the loading of Nuvec® silica particles with plasmid. The efficacy of product de-agglomeration as well as potential damage to the silica particle structure were also assessed. Its study concludes that Nuvec® may provide protection to the DNA plasmid from degradation, therefore suggesting that Nuvec® has the potential to be successfully used to deliver oligomers including plasmid DNA, mRNA or siRNA to tumours.

Article: Deagglomeration of DNA nanomedicine carriers using controlled ultrasonication