Announcement PDF RNS Number : 8226Y N4 Pharma PLC 14 September 2020 14 September 2020 N4 Pharma plc ("N4 Pharma" or the "Company") Covid-19 Proof of Concept Update and move to in vivo study N4 Pharma Plc (AIM: N4P), the specialist pharmaceutical company developing, a novel delivery system for cancer treatments and vaccines, provides an update on its Covid-19 proof of concept work utilising Nuvec® loaded with Coronavirus plasmid. As announced on 12 August 2020, stage 2 of the proof of concept work was successfully completed with the transfection of HEK (Human Embryonic Kidney) cells of Nuvec® loaded with Coronavirus plasmid in vitro. Following the completion of stage 3 of the proof of concept work and a review of the results, the Company is continuing to explore the utility of Nuvec® with the Coronavirus plasmid and will progress to an in vivo study in due course. Whilst the single intradermal injection used in the stage 3 pre (pilot) in vivo study did not result in a measurable expression of the spike protein in the target cells of the murine target, neither did the positive control. Additional exploratory studies will continue to understand the translation potency of the Coronavirus plasmid including optimisation of Nuvec® plasmid loading. With this in mind and taken together with previous positive data, the Company has decided to proceed to a full in vivo study to demonstrate the capability of Nuvec® to generate Covid-19 specific antibodies. The Company is in the process of scoping the programme of studies required. Nigel Theobald, Chief Executive Officer, commented: "The initial pilot work of stage 3 of the Covid-19 proof of concept work was narrow in its scope and, having reviewed the results, we have taken the decision to move to a full in vivo study to establish an immune response through the production of antibodies. In undertaking the work we aim to demonstrate Nuvec®'s capabilities both as a potential delivery technology for multiple vaccines as well as for Covid-19 specifically. I look forward to providing further updates in due course." The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulations (EU) No. 596/2014. Enquiries: N4 Pharma plc Nigel Theobald, CEO Luke Cairns, Executive Director SP Angel Corporate Finance LLP Nominated Adviser and Joint Broker Matthew Johnson/Caroline Rowe (Corporate Finance) Vadim Alexandre/Abigail Wayne/Rob Rees (Corporate Broking) Turner Pope Investments (TPI) Limited Joint Broker Andy Thacker IFC Advisory Ltd Financial PR Graham Herring Zach Cohen Via IFC Advisory Tel: +44(0)20 0470 3470 Tel: +44(0)20 0050 3657 Tel: +44(0)20 6630 3934 About N4 Pharma N4 Pharma is a specialist pharmaceutical company developing a novel delivery system for cancer and vaccine treatments using its unique silica nanoparticle delivery system called Nuvec®. N4 Pharma's business model is to partner with companies developing novel antigens for cancer and vaccine treatments to use Nuvec® as the delivery vehicle to get their antigen into cells to express the protein needed for the required immunity. As these products progress through pre clinical and clinical programs, N4 Pharma will seek to receive up front payments, milestone payments and ultimately royalty payments once products reach the market. This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com. RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy. END UPDKXLFFBKLXBBB