RNS Number : 7150M Thalia Therapeutics PLC 17 July 2026 17 July 2026 Thalia Therapeutics plc ("Thalia" or the "Company") AGM Statement Thalia Therapeutics plc (AIM: THAT), a biotechnology company developing innovative RNA-based therapeutics and delivery technologies in oncology and cardiovascular disease, will hold its Annual General Meeting ("AGM") today at 11.00 a.m. at the offices of Arch Law Limited, Huckletree Bishopsgate, 8 Bishopsgate, London, EC2N 4BQ. Dr David Solomon, Chief Executive Officer, will provide the following statement: "The past few months have marked a significant period in Thalia's evolution. Following our strategic repositioning as an RNA therapeutics company, the proposed acquisition of Sanmirna Therapeutics and the associated £2.75 million oversubscribed fundraise represent a transformational step, accelerating our transition into a clinical-stage biotechnology company and significantly strengthening our differentiated RNA therapeutics pipeline. "Subject to shareholder approval today, the acquisition will add miRisten, a Phase 1 clinical-stage microRNA therapeutic for Acute Myeloid Leukaemia, alongside our proprietary Nuvec® delivery technology and our dual- targeting cardiovascular siRNA programme. Together, these create a diversified portfolio of innovative RNA therapeutics addressing significant unmet medical needs across oncology and cardiovascular disease, targeting multi-billion-dollar global markets. "With funding in place for our planned work streams across the portfolio, including the completion of the Phase 1 clinical trial for miRisten, the Board believes Thalia is well positioned to deliver the next phase of its development and a number of important value-creating milestones. Our immediate priorities are to fully integrate Sanmirna following completion of the acquisition; complete the ongoing Phase 1 miRisten clinical study, which remains open and ongoing with patient enrolment temporarily paused while the current cohort progresses through the study, ahead of topline data expected in the first half of 2027 and subsequent preparation for Phase 2; advance our cardiovascular programme towards IND-enabling studies; and continue developing Nuvec® as a differentiated RNA delivery platform. "Thalia is entering an exciting new phase of development and the Board would like to thank investors for their continued support. Subject to shareholder approval, we look forward to completing the acquisition and continuing to build a leading clinical-stage RNA therapeutics company. We remain focused on executing our strategy and look forward to updating the market as we advance our asset pipeline." - Ends - For more information please contact: Thalia Therapeutics plc Dr David H Solomon, Chief Executive Officer Via Thalia Investor Hub https://investors.thaliatx.com/link/eY0WWy SP Angel Corporate Finance LLP Nominated Adviser and Joint Broker Matthew Johnson/Jen Clarke (Corporate Finance) Vadim Alexandre/Abigail Wayne/Rob Rees (Corporate Broking) Tel: +44 (0)20 3470 0470 Turner Pope Investments (TPI) Limited Joint Broker Andy Thacker/Guy McDougall Tel: +44 (0)20 3657 0050 Northstar Communications Limited Investor relations and Communications Sarah Hollins Cohesion Bureau Investor relations and Communications Mary-Ann Chang Tel: +44 (0)20 7183 2463 Tel: +44 (0)7483 284853 About Thalia Therapeutics plc Thalia Therapeutics is a biotechnology company developing innovative RNA-based therapeutics and delivery technologies in oncology and cardiovascular disease. With a growing, differentiated pipeline, de-risked by validated therapeutic targets, we aim to treat diseases at the source by silencing or modifying the genes that cause or contribute to them. Our preclinical bispecific siRNA is a potentially long-acting treatment for atherosclerotic cardiovascular disease, which addresses two independent drivers of cardiovascular risk. Our proprietary delivery technology, Nuvec®, offers the potential to overcome the fundamental challenges of RNA delivery, enabling targeted, scalable RNA therapeutics. For further information visit www.thaliatx.com This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com. RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy. END AGMAKABPABKDKOD